Kidney Week Educational Symposia-Imaging and Multidisciplinary Care in ADPKD

Video Transcription

Video Summary

The symposium “Imaging and Multidisciplinary Care in PKD” focused on improving communication between radiologists and nephrologists, optimizing imaging for diagnosis/prognosis, and building better multidisciplinary care for ADPKD patients. Terri Watnick opened with a case of a 46-year-old man labeled as ADPKD despite normal-sized kidneys and negative PKD1/PKD2 testing; the true cause was an IFT140 pathogenic variant, illustrating the importance of recognizing atypical genetic etiologies and interpreting “negative” tests carefully.<br /><br />Michael M. (Murug) argued that traditional referral-based care is often late and fragmented. He proposed ADPKD-centered clinics as hubs for earlier diagnosis, genetic counseling/testing, standardized risk stratification using total kidney volume and the Mayo Imaging Classification, access to tolvaptan (including handling REMS burdens), protocolized CKD care, cyst interventions, and coordinated management of extrarenal disease (liver cysts, aneurysms, cardiac issues), pain, mental health, nutrition, and reproductive counseling. He highlighted future directions including telehealth, digital self-management tools, new therapeutics, and imaging advances.<br /><br />Timothy Klein described gaps in radiology reporting and the need for standardized, structured reports. He showed how AI-driven segmentation and 3D volumetrics can quantify kidney/liver volumes, cyst number/size, and parenchymal texture to improve prognostic models beyond TKV alone, alongside emerging quantitative MRI and 3D ultrasound. Discussion emphasized developing joint radiology-nephrology reporting templates and keeping humans “in the loop” for AI outputs.

Asset Subtitle

Moderator(s): Terry Watnick

Presentation(s):

Introduction - Terry Watnick
ADPKD Clinic: Optimizing Workforce Teamwork and Patient-Centered Care - Michal Mrug
Radiographic Imaging to Refine Diagnosis and Prognosis in ADPKD - Timothy Kline

Support is provided by an educational grant from Otsuka America Pharmaceutical, Inc.

Meta Tag

Date 10/24/2024

Pathway 1 Genetic Diseases and Development

Session ID 495597

Session Type ES - Educational Symposium

Keywords

Autosomal dominant polycystic kidney disease (ADPKD)

Multidisciplinary PKD clinic model

Radiology-nephrology communication

Total kidney volume (TKV)

Mayo Imaging Classification

Genetic testing and atypical PKD (IFT140)

AI-driven segmentation and 3D volumetrics

Structured radiology reporting templates