Kidney Week 2025 Early Program - Care of Kidney Transplant Candidates and Recipients-Moderated Discussion

Video Transcription

Video Summary

The transcript captures a Q&A session at a transplant meeting focused mainly on how clinicians manage immunosuppression after kidney transplant failure and how “unlikely to get transplanted in five years” is interpreted. Speakers note that the “five-year unlikely” threshold is not clearly defined as a specific percentage and is often center-dependent.<br /><br />Panelists emphasize there is no standardized protocol for tapering immunosuppressive drugs; decisions are individualized based on re-transplant candidacy, expected time to re-transplant, blood type, risk of sensitization, side effects (e.g., osteoporosis), residual urine output, and patient preferences. Some centers continue low-dose tacrolimus and/or prednisone if re-transplant is likely soon (e.g., within 6 months), taper more aggressively if not, and sometimes maintain prednisone 5 mg due to cost and tolerability. A 2023 study is mentioned suggesting continued therapy may reduce rejection, hospitalization, and mortality, but more research is needed.<br /><br />Later, a question addresses porcine CMV risk in xenotransplantation, highlighting newer serology and designated pathogen-free facilities with routine screening.

Asset Subtitle

Harini A. Chakkera, Syed Ali Husain, Vineeta Kumar, Roslyn B. Mannon, Naoka Murakami, Karin A. True

Meta Tag

Module TRX

Speaker FACULTY FACULTY

Keywords

kidney transplant failure

immunosuppression tapering

re-transplant candidacy

five-year unlikely threshold

sensitization risk

porcine CMV xenotransplantation