Kidney Week 2025 Early Program - Care of Kidney Transplant Candidates and Recipients-Causes of ESKD and Their Impact on Kidney Transplant Evaluation

Causes of ESKD and Their Impact on Kidney Transplant Evaluation

Video Transcription

Video Summary

The speaker reviews whether determining the cause of end-stage kidney disease (ESKD) before transplant matters. Most ESKD is labeled diabetes or hypertension, with many “unknown,” suggesting misclassification due to limited biopsy/genetic workup. Etiology distribution is similar among waitlisted patients. For glomerular diseases, diagnosis matters because recurrence increases over time (about 10–20% by 15 years) and reduces graft survival, especially for MPGN. In FSGS, response to treatment improves outcomes; genetic FSGS shows near-zero recurrence and poor immunosuppression response, while non-genetic has higher recurrence. Emerging biomarkers (e.g., anti-nephrin, anti-gdIgA1, PLA2R) may predict recurrence and guide management.

Asset Subtitle

Dana Rizk

Meta Tag

Module TRX

Speaker Dana Rizk

Keywords

end-stage kidney disease etiology

kidney transplant recurrence risk

focal segmental glomerulosclerosis (FSGS) genetics

membranoproliferative glomerulonephritis (MPGN) graft survival

glomerular disease biomarkers (PLA2R, anti-nephrin, anti-gdIgA1)