Kidney Week 2025 Annual Meeting-Transplantation: Basic Science Innovations and Advances

Video Transcription

Video Summary

The session “Transplantation: Basic Science, Innovations, and Advances” featured multiple talks spanning innate immunity, xenotransplant physiology, transplant genetics, cancer biomarkers, and immune monitoring.<br /><br />Arvind Chirakuri (Pittsburgh) described “innate allorecognition” mediated by donor–recipient mismatches in SIRPα (on myeloid cells) interacting with CD47. In mouse kidney transplants, eliminating SIRPα mismatch or CD47 reduced inflammation, fibrosis, and activated myeloid/T-cell infiltrates. In two human cohorts (Pittsburgh and Northwestern), a high-affinity donor to low-affinity recipient SIRPα mismatch (B→A) associated with more rejection, early fibrosis/IFTA, altered monocyte phenotypes, and worse graft survival, suggesting a potential pretransplant risk-stratification tool and possible targeting of the CD47 axis.<br /><br />Maho Terashita (MGH) examined RAAS dysfunction in pig-to-baboon kidney xenotransplantation. Pig renin was not detectable post-transplant; baboons with retained (ureter-ligated) native kidneys maintained baboon renin and had more stable creatinine and electrolytes than bilaterally nephrectomized animals, implying hypovolemia seen in models may be less relevant clinically where native kidneys remain.<br /><br />John Pell (Yale) presented mechanistic data linking recipient APOL1 risk variants (G1/G2) to intrinsically hyperactive CD8 T cells via dysregulated ER calcium depletion, enhanced store-operated calcium entry, and calcineurin signaling, contributing to accelerated rejection and relative tacrolimus resistance; an APOL1 inhibitor reversed ex vivo phenotypes.<br /><br />Carlo Alfieri (Milan) reported the COMETA multicenter study identifying serum microRNA signatures tied to transplantation and post-transplant cancer risk, highlighting a strong cancer-associated miRNA signal (e.g., miR-210), with prospective validation planned.<br /><br />Other talks covered ESRD patient PBMC-driven renal lymphatic remodeling (Vanderbilt), a glutathione-based single-cell redox biosensor for functional immunosuppression monitoring (Charité), immunologic correlates of post-transplant erythrocytosis/EPO (Einstein/Mount Sinai), estrogen receptor effects on ischemia–reperfusion tolerance (Penn), and regulatory B-cell phenotypes associated with better graft outcomes (Mostafa Ali).

Asset Subtitle

Moderator(s): Jonathan Maltzman, Martin Oberbarnscheidt

Presentation(s):

Innate Allorecognition and Kidney Transplant Outcomes - Aravind Cherukuri
RAAS in Pig-to-Baboon Kidney Xenotransplantation: Relevance to Clinical Use - Maho Terashita
APOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection - John Pell
The COMETA Study: A systems biology approaCh to the mOlecular (miRNA) profiling of the nEoplastic risk in kidney TransplAnt recipients - Carlo Alfieri
ESRD Patient-Derived Immune Cells Direct Lymphatic Remodeling and Modulate Response to Kidney Injury - Jing Liu
Application of a Glutathione (GSH)-Sensitive Biosensor to Monitor Single-Cell Redox Profiles in Immunosuppressed Human Cells and Kidney Transplant Patients: A Feasibility Study - Nina Goerlich
Increased Treg and Erythropoietin Levels in Kidney Transplant Recipients (KTR) with Erythrocytosis - Maria Ajaimy
Differential Effects of Estrogen Receptor (ER)-alpha and ER-beta on Female Tolerance of Kidney Ischemia-Reperfusion Injury - Matthew H. Levine
Regulatory B Cell Phenotypes in Kidney Transplant Recipients and Their Association with Graft Function - Mostafa Aly

Note: Continuing education credits are not being offered for this session.

Meta Tag

Date 11/7/2025

Pathway 1 Kidney Transplantation

Session ID 519901

Keywords

innate allorecognition

SIRPα–CD47 axis

kidney transplantation rejection risk

xenotransplantation pig-to-baboon kidney

RAAS dysfunction renin hypovolemia

APOL1 G1/G2 risk variants

CD8 T-cell hyperactivity calcineurin signaling

tacrolimus resistance

serum microRNA cancer biomarkers miR-210

immune monitoring single-cell redox biosensor glutathione

renal lymphatic remodeling PBMC ESRD

regulatory B-cell phenotypes graft survival