Kidney Week 2025 Annual Meeting-CKD in the US Hispanic/Latino Population

Video Transcription

Video Summary

The session “CKD in the U.S. and Hispanic Populations” reviewed epidemiology, risk factors, genetics, access to care, and a specific CKD entity affecting agricultural communities.<br /><br />Dr. Anna Ricardo summarized data showing Hispanics are ~20% of the U.S. population and have about twice the ESRD prevalence of White people, despite similar overall CKD prevalence (~14%), largely driven by albuminuria. Using the HCHS/SOL cohort, CKD prevalence and incidence varied by Hispanic heritage, highest among Puerto Ricans and lowest among South Americans, and were generally lower when using the 2021 race-free eGFR equation. Independent CKD incidence risk factors included higher blood pressure, HbA1c, albuminuria, and inflammation; sedentary time strongly predicted incident CKD. Better cardiovascular health (Life’s Essential 8) was linked to slower eGFR decline. In CRIC, Hispanic participants had steeper eGFR decline and higher ESRD rates than Whites, largely explained by higher proteinuria, and also reported less nephrology care and poorer achievement of CKD management targets; poorer primary care experience correlated with higher hospitalization risk.<br /><br />A second speaker focused on barriers and strategies for uninsured/undocumented immigrants, highlighting language access gaps, fear driven by anti-immigrant policies, and shrinking insurance eligibility. Colorado examples included community-based prevention programs, CHW navigation interventions, expanded emergency Medicaid to cover ongoing dialysis and other chronic conditions, and state-funded “Medicaid-like”/private coverage programs; policy changes can reduce costs versus emergency-only care.<br /><br />Dr. Nora Franceschini discussed polygenic risk scores (PRS): Hispanic/Latino genetic diversity and underrepresentation limit PRS portability and performance; current CKD PRS add modest discrimination beyond clinical factors, underscoring the need for more diverse GWAS.<br /><br />Dr. David Sheikh-Hamad presented research on CKD of unknown etiology (Mesoamerican nephropathy/CINAC), linking risk to agrochemical exposure—especially paraquat—and developing a mouse model showing male-predominant kidney-specific fibrosis/inflammation, implicating transporters (OCT2, MATE1) and ROS–lysosomal dysfunction pathways. The Q&A emphasized community strengths such as information-sharing networks that can amplify education and uptake of therapies.

Asset Subtitle

Moderator(s): Magdalena Madero, Sylvia Rosas

Presentation(s):

Understanding Risk Factors for Incident CKD and CKD Progression in the US Hispanic Population - Ana Ricardo
Enhancing Care for Uninsured Hispanic Immigrants with CKD: Overcoming Barriers and Expanding Access - Lilia Cervantes
Utility of Polygenic Risk Scores for CKD in Hispanic Populations - Nora Franceschini
CKD of Unknown Etiology (CKDu): Findings from Recent Studies - David (Daud) Sheikh-Hamad

Meta Tag

Date 11/6/2025

Pathway 1 CKD Non-Dialysis

Session ID 507214

Keywords

chronic kidney disease (CKD)

Hispanic/Latino populations

end-stage renal disease (ESRD) disparities

albuminuria and proteinuria

HCHS/SOL cohort

CRIC study

race-free eGFR 2021 equation

Life’s Essential 8 cardiovascular health

incident CKD risk factors (BP, HbA1c, inflammation)

sedentary time and kidney outcomes

access to nephrology care and care barriers

uninsured/undocumented immigrants and Medicaid policy

Mesoamerican nephropathy (CINAC) and paraquat exposure