Kidney Week 2025 Annual Meeting-Best of ASN Journals: JASN, CJASN, and Kidney360

Video Transcription

Video Summary

The session introduced the “Best of ASN Journals” format and explained how topics were chosen by ASN communications leadership and papers then selected by associate editors for impact. It opened with a new ASN Kidney Health Guidance document on potassium and phosphorus food additives, led by an interdisciplinary workgroup. The guidance emphasizes that additives in processed foods have high bioaccessibility/bioavailability compared with plant sources, yet labeling is limited (potassium amounts aren’t distinguished as natural vs additive; phosphorus often isn’t listed). The group proposed tiered counseling strategies—basic, advanced, intensive—based on patient risk (hyperkalemia or CKD–mineral bone disorder), barriers, and need for renal dietitian involvement. Recommendations include prioritizing minimally processed foods, avoiding salt substitutes and “enhanced” meats, reading ingredient lists (e.g., “PHOS”), and individualized diet histories. Evidence cited included potassium chloride supplementation increasing serum potassium in CKD and short trials showing reduced phosphate additives can lower urinary phosphorus and CKD-MBD biomarkers.<br /><br />A genetics-focused segment highlighted three papers: (1) a Drosophila nephrocyte phenotypic drug-screening platform modeling podocyte injury via RAC1, identifying zacopride as a candidate protective compound; (2) UK Biobank data showing hypertension polygenic risk amplifies the association between self-reported salt use and incident CKD; and (3) serine nucleic acid anti–miR-21 therapy reducing cyst growth and fibrosis in cystic kidney disease models.<br /><br />Home dialysis papers covered genetic determinants of peritoneal ultrafiltration (including a PTGES/PGE2 mechanism), feasibility of nurse-assisted PD to keep patients on home therapy, and a single-center study suggesting urgent-start PD can achieve similar short-term outcomes to HD in severely uremic hospitalized patients. The final cardiovascular-kidney segment reviewed: Life’s Essential 8 and CKD progression in Hispanic/Latino adults, mortality across CKM syndrome stages in NHANES, and associations between metabolic acidosis and cardiovascular markers in children with CKD.

Asset Subtitle

Moderator(s): Amanda Anderson, David Ellison

Presentation(s):

ASN Kidney Health Guidance on Potassium and Phosphorus Food Additives - Annabel Biruete
Best of Genetics - Simone Sanna-Cherchi
Best of Home Dialysis - Tammy Sirich
Best of Kidney in Cardiovascular Disease - Tazeen Jafar

ASN thanks JASN, CJASN, and Kidney360 for assistance with this session.

Meta Tag

Date 11/6/2025

Pathway 1 Other

Session ID 506847

Keywords

ASN Best of ASN Journals

Kidney Health Guidance

potassium food additives

phosphorus food additives

processed foods bioavailability

food labeling limitations

tiered dietary counseling

hyperkalemia management

CKD–mineral bone disorder (CKD-MBD)

renal dietitian referral

salt substitutes potassium chloride

phosphate additives reduction

podocyte injury RAC1 Drosophila screen

hypertension polygenic risk UK Biobank salt use CKD

peritoneal dialysis ultrafiltration genetics PTGES PGE2